An introduction to the thematic issue of Forum Historiae 1/2021, Italy and the Post-Habsburg Central Europe outlines the main research questions and hypotheses that the authors worked with. Italy had ambitions to be in the position of a great power in the region and played an important role there in several different dimensions. The papers of this volume examine the political, diplomatic and military aspects of the Italian presence, as well as its economic, local and social dimension in post-Habsburg Central Europe. The intention of this thematic issue is not to cover the matter in its entirety, but rather to focus on lesser-known topics or those that have yet to be researched.